The Nucleolus under Stress
نویسندگان
چکیده
منابع مشابه
The Nucleolus Takes Control of Protein Trafficking Under Cellular Stress.
The nucleolus is a highly dynamic nuclear substructure that was originally described as the site of ribosome biogenesis. The advent of proteomic analysis has now allowed the identification of over 4500 nucleolus associated proteins with only about 30% of them associated with ribogenesis (1). The great number of nucleolar proteins not associated with traditionally accepted nucleolar functions in...
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When cells are observed by phase contrast microscopy, nucleoli are among the most conspicuous structures. The nucleolus was formally described between 1835 and 1839, but it was another century before it was discovered to be associated with a specific chromosomal locus, thus defining it as a cytogenetic entity. Nucleoli were first isolated in the 1950s, from starfish oocytes. Then, in the early ...
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Are they always about? Not necessarily. They come and go, disappearing in mitosis from late prophase until telophase. During this period, some nucleolar antigens, including RNA polymerase I and topoisomerase I, remain associated with tandemly repeated clusters of ribosomal RNA genes on the condensed chromatin — these chromosomal regions are presumptuously known as nucleolar organising regions (...
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I discuss thermal, rheological and compositional definitions of the Earth’s lithosphere and describe the data that can be brought to bear in refining these definitions. Models of the behaviour of the lithosphere are useful in describing such diverse effects as continental basin subsidence, the flexural response to imposed loads such as seamounts or sediment accumulations, the partial melting of...
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In most economic applications, externalities prevail: the worth of a coalition depends on how the other players are organized. We show that there is a unique natural way of extending the nucleolus from (coalitional) games without externalities to games with externalities. This is in contrast to the Shapley value and the core for which many different extensions have been proposed.
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2010
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2010.09.024